NGP-NET 2016

Scientific Program

Day 1 (Thursday, September 15, 2016)
Session 1
Chair: Silvio Tosatto
08:00 - 09:00Registration
09:00 - 09:10Nevena Veljkovic, Serbia
09:10 - 09:30Silvio Tosatto, Italy
Introduction to NGP-net
09:30 - 10:00Burkhard Rost, Germany
Implications of dark proteome for personalized health
10:00 - 10:30 Rohit Pappu, USA
Conformations and molecular functions encoded by sequence patterns of non-globular proteins
10:30 - 10:50Andrey Kajava, France
A Census of Tandem Repeats in Proteomes
10:50 - 11:20Coffee break
Session 2
Chair: Sonia Longhi
11:20 - 11:50Stefano Gianni, Italy
Understanding the mechanisms of folding and binding of intrinsically disordered proteins
11:50 - 12:20 Edward Lemke, Germany
Decoding Molecular Plasticity in the Dark Proteome
12:20 - 12:40 Arne Elofsson, Sweden
High GC Content Causes Young Proteins to be Intrinsically Disordered
12:40 - 13:00Flash presentations
13:00 - 15:00Lunch & Poster session (Odd numbered posters)
Session 3
Chair: Rohit Pappu
15:00 - 15:30Ehud Gazit, Israel
From Biological Self-Assembly to Novel Peptide Nanostructures of Unique Mechanical, Optical, Piezoelectric and Semiconductive Properties
15:30 - 16:00Johnny Habchi, UK
Systematic development of small molecules and characterization of their effect on ΑΒ42 aggregation at a single microscopic step level
16:00 - 16:20Aitziber L. Cortajarena, Spain
Designed proteins scaffolds to stabilize nanoclusters: sensing and imaging appliactions
16:20 - 16:40Pietro Sormanni, UK
Rational design of binding proteins targeting specific epitopes within intrinsically disordered proteins
16:40 - 17:10Coffee break
Session 4
Chair: Arne Elofsson
17:10 - 17:40Norman Davey, Ireland
Discovery and Characterisation of Novel Functional Modules in Intrinsically Disordered Regions
17:40 - 18:00Edoardo Salladini, France
Preliminary characterization of the Henipavirus V protein and its interaction with the cellular protein DDB1
18:30Belgrade tour and dinner at the restaurant Gabiano (
Day 2 (Friday, September 16, 2016)
Session 5
Chair: Stefano Gianni
9:00 - 9:30Alasdair Steven, USA
Order-Disorder Transitions of Coiled-coil Barrels During Virus Assembly
9:30 - 10:00Fabrizio Chiti, Italy
The mechanism of aggregation of non-globular proteins
10:00 - 10:20Salvador Ventura, Spain
Repositioning Tolcapone as a potent inhibitor of transthyretin amyloidogenesis and its associated cellular toxicity
10:20 - 10:40Ramon Crehuet, Spain
Modelling Intrinsically Disordered Proteins. Challenges when comparing to experiments
10:40 - 11:10Coffee break
Session 6
Chair: Andrey Kajava
11:10 - 11:40Diego Ferreiro, Argentina
Inferring folding energy landscapes from repeat-protein sequences
11:40 - 12:10Fabio Parmeggiani, UK
Novel repeat protein families: design, assembly and polymerization
12:10 - 12:30Lisanna Paladin, Italy
Tandem Repeat proteins at a glance: functions, diseases and role in protein-protein interaction network
12:30 - 12:55Flash presentations
13:00 - 15:00Lunch & Poster session (Even numbered posters)
Session 7
Chair: Isabelle Landrieu
15:00 - 15:30Philippe Minard, France
AlphaRep: a library of artificial repeat proteins as an efficient source of specific binding proteins
15:30 - 15:50Elena Papaleo, Denmark
To unravel at the atom-level intrinsically disordered proteins and the effects induced by cancer alterations integrating enhanced sampling simulations and biophysical techniques
15:50 - 16:10Turkan Haliloglu, Turkey
Collective Dynamics and Modulation of Function
16:10 - 16:30 San Hadzi, Slovenia
Intrinsic disorder is at hart of the ratio-dependent autoregulation in two-gene bacterial operon
16:30 - 17:00Coffee break
Session 8
Chair: Salvador Ventura
17:00 - 17:30Simon Alberti, Germany
Three complementary mechanisms of quality control ensure RNP granule functionality and dynamics
17:30 - 17:50Bente Vestergaard, Denmark
Structural Studies of Amyloid-like Protein Fibrillation
17:50 - 18:10Oxana Galzitskaya, Russia
The mechanism underlying amyloid polymorphism is opened for Alzheimer's disease ΑΒ peptide
18:10 - 18:30Mariana Amoroso das Neves Romão, Portugal
S100 proteins as novel modifiers of proteostasis in health and disease
18:30 - 18:50Lucia Chemes, Argentina
Linear motif combination and conservation of flexibility determines the displacement ability of an intrinsically disordered viral oncoprotein
20:00Dinner at the hotel
Day 3 (Saturday, September 17, 2016)
Session 9
Chair: Alasdair Steven
9:00 - 9:30Rob Finn, UK
Recognising intrinsically disordered regions in protein family databases
9:30 - 10:00Andrei Lupas, Germany
Coiled coils - between structure and unstructured
10:00 - 10:20Pau Bernado, France
Disentangling polydispersity for the PCNA-p15 interaction: A disordered, transient and multivalent macromolecular assembly
10:20 - 10:40Georgios Skretas, Greece
Molecular evolution of short cyclic peptides that rescue the misfolding, aggregation, and the associated pathogenic effects of proteins linked to protein misfolding diseases
10:40 - 11:10Coffee break
Session 10
Chair: Zsuzsanna Dosztanyi
11:10 - 11:40Laura Itzhaki, UK
Engineering folding and function of tandem-repeat proteins
11:40 - 12:00Isabelle Landrieu, France
Modulation of neuronal tau protein interaction with protein partners
12:00 - 12:20Diana Fedunova, Slovakia
Inhibiting activity of fullerenol C60(OH)16 on ΑΒ1-40 amyloid aggregation - in vitro and in silico study
12:20 - 12:55Flash presentations
12:55 - 13:00Nevena Veljkovic, Serbia
Closing remarks
13:00 - 14:30Lunch
14:30 - 16:30WG Meetings
16:30 - 17:00Coffee break
17:00 - 17:30WG leaders
WG meeting summaries
17:30 - 18:30Planning for projects
20:00Dinner at Mali vrabac (

COST Institute of Nuclear Sciences VINCA